The 'Sing' hitmaker has been announced to perform at the month-long series of gigs at The Roundhouse in Camden, north London, on September 29.
'Bang Bang' singer Jessie will perform on September 22 and US R&B star Mary will headline the September 25th show.
Ed said: ''I'm very happy to be playing my third iTunes Festival next month. I first played supporting Bruno Mars in 2011 and then came back the next year for my own.''
Mary added: ''I'm so happy to be playing for my first time at iTunes Festival. I've always loved visiting London and I can't wait to be back to see my UK fans next month.''
US crooner Tony Bennett - who is due to release an album with Lady Gaga - has also been announced for the festivities.
He commented: ''I'm thrilled to be back at iTunes Festival once again. It's a phenomenal musical experience for both the performers and the audience and I love being part of it!''
iTunes Festival 2014 line-up:
September 1 - deadmau5
September 2 - Beck and Jenny Lewis
September 3 - David Guetta, Clean Bandit and Robin Schulz
September 4 - 5 Seconds of Summer and Charlie Simpson
September 5 - Kasabian
September 6 - Tony Bennett
September 7 - Calvin Harris and Kiesza
September 8 - Robert Plant and Luke Sital-Singh
September 9 - Sam Smith and SOHN
September 10 - Pharrell Williams and Jungle
September 11 - Maroon 5, Matthew Koma and Nick Gardner
September 12 - Elbow and Nick Mulvey
September 13 - Paolo Nutini and Rae Morris
September 14 - David Gray and Lisa Hannigan
September 15 - The Script and Foxes
September 16 - Blondie and Chrissie Hynde
September 17 - Gregory Porter and Eric Whitacre
September 18 - Jessie Ware and Little Dragon
September 20 - Rudimental and Jess Glynne
September 21 - Ryan Adams and First Aid Kit
September 22 - Jessie J and James Bay
September 23 - Placebo
September 24 - Ben Howard and Hozier
September 25 - Mary J. Blige
September 26 - Lenny Kravitz and Wolf Alice
September 27 - Kylie and MNEK
September 28 - Nicola Benedetti, Miloš and Alison Balsom
September 29 - Ed Sheeran and Foy Vance
Jack Antonoff hears a ''female voice'' in his head when he writes music.
The show will be seen by everybody at the same time.
The Scottish comedian has been speaking about gaining a knighthood in the Queen's Birthday Honours List.
With Will Smith and Martin Lawrence fronting the franchise, 'Bad Boys' was a huge success for Sony Pictures upon its initial release in 1995.
The creator will be able to give her input during season 2 production.
As it's been 12 years since the last Bridget Jones movie, expectations aren't too high...
Bridget has always known how to get herself into a muddle - catastrophic muddles at...
After battling the dating scene and finally finding love with Mark Darcy, Bridget Jones is...
In July of 2015, Ed Sheeran played his biggest gigs to date, selling out Wembley...