Drew Barrymore and Anjelica Huston's publicist Eddie Michaels has lost his battle with cancer at the age of 49.

The Hollywood representative passed away on Thursday (08Aug13) in Los Angeles after a long fight against brain cancer, according to his wife Lorin.

In a blog post on Thursday, she wrote, "Tonight after 7 years of various treatments, setbacks, hopes, dreams, successes, trials, perseverance, fight, commitment and love for the kids and me, Eddie finally laid down his sword and stopped the fight with the kids' and my blessing..."

Michaels began his career with his mentor, Joe Sutton, at Freeman & Sutton. In 1992, he founded Eddie Michaels & Associates and relaunched it as Insignia Public Relations in 2004.

Throughout his career, Michaels represented many of Hollywood's top stars, including Barrymore, Huston, Noah Wyle, Lou Diamond Phillips, Jeremy Piven, Marg Helgenberger, Mary Steenburgen, Patrick Dempsey, Jason Biggs and Dougray Scott, among many others.

A statement issued by former Er star Wyle reads: "Eddie was indeed of the old school but never became cynical. He was experienced but without being jaded. Above all, he was honest, sometimes painfully so, but that only made him more trustworthy. In an industry fueled by hyperbole, his candor was refreshing, his perspective invaluable."

A funeral is due to take place at Mount Sinai Memorial Park on Sunday (11Aug13). In lieu of flowers, family members have asked that donations be made in Michaels' honour to Wilshire Boulevard Temple or to the Johnnie Cochran Brain Institute.