The Material Girl icon thrilled fans by joining Drake during his headlining set on 12 April (15) as he performed a track named after Madonna.

She then launched into a medley of her own hits, including Human Nature and Express Yourself, and as she wrapped up her appearance, she walked up behind a seated Drake, pulled his head back and started to kiss him passionately.

However, video footage of the moments following the kiss appear to show the hip-hop star grimacing as he wipes his mouth, while Madonna struts offstage.

He subsequently took to Twitter.com to insist he was simply in awe, telling fans, "Don't misinterpret my shock!! I got to make out with the queen Madonna and I feel (great) about that forever. Thank you @Madonna."

But Madonna is not convinced by his explanation and she has since hit out at the Started From The Bottom hitmaker.

During a question and answer session online, Madonna was asked if Drake was a good kisser, to which she replied, "You asked the million dollar question. I kissed a girl, and I liked it" - referring to her famous smooch with Britney Spears at the 2003 MTV Video Music Awards.

She followed it up by sharing a little advice to her younger self, sniping, "Don't kiss Drake. No matter how many times he begs you to."