Trump's surprise victory last week (end13Nov16) denied Hillary Clinton the chance to become America's first female president.
Accepting the inaugural Man of the Year prize at Glamour magazine’s Women of the Year Awards on Monday (14Nov16), the U2 frontman, real name Paul Hewson, called on the incoming president to address concerns he will not be a champion for gender equality.
"I say to the president-elect: ‘Look across to women’," Bono said. "Make equality a priority. It is the only way forward. The train is leaving the station. Be on it or be under it."
In his speech the Elevation singer, 56, expressed his fear that Trump's election and the British public voting to leave the European Union were setbacks for racial and gender equality.
"2016 might have been the year when I stopped believing Martin Luther King Jr. when he said, ‘The arc of the moral universe is long, but it bends toward justice,’" he mused. "This might be the year when I stop believing that progress for equality was inevitable—that the momentum is unstoppable."
Bono's award was itself controversial, with many initial reports mocking the notion that he would be honoured at the prizegiving, which has previously only recognised extraordinary achievements by women.
The rocker, who was singled out after his charity One launched an anti-sexism campaign last year (15), addressed the controversy in his speech.
"I know how ridiculous it is for me to be on this stage accepting this award," he said. "But if I didn't know how ridiculous it was, I did have the blessed internet to remind me."
However he said it was up to both men and women to address sexism, adding, "Unless we address this problem, both men and women together, the world will continue down this misogynistic, violent and impoverished path."
Other honourees at the ceremony included Gwen Stefani, Olympic gymnast Simone Biles, pop star Zendaya and Christine Lagarde, the Managing Director of the International Monetary Fund.