The 'I Remember' dance musician famously criticised Madonna after she appeared to ask fans who was taking DRUGS at one of her concerts, and has now said she should stay away from dance music.
He said: ''You want to be 'hip' and 'cool' and 'funky grandma'? Fine. It's not my place to say you're irrelevant. If you're gonna come into my world, at least do it with a little more dignity.
''I understand she has millions more fans, and is way more successful than I'll ever be. But it's like talking about slavery at a f***ing blues concert. It's inappropriate.''
deadmau5 - real name Joel Zimmerman - also criticised two of the biggest DJs in the world, claiming there is very little skill in the way they perform.
He told Rolling Stone magazine: ''David Guetta has two iPods and a mixer and he just plays tracks - like, 'Here's one with Akon, check it out!'''
''Even Skrillex isn't doing anything too technical. He has a laptop and a MIDI recorder, and he's just playing his s**t.
''People are, thank God, smartening up about who does what - but there's still button-pushers getting paid half a million. And not to say I'm not a button-pusher. I'm just pushing a lot more buttons.''