Gilmour insists he will never perform with the Wish You Were Here rockers again, and will instead concentrate on his solo career.
However, he is keen to point out the decision is not a result of his fractured relationship with Pink Floyd bassist Roger Waters.
In an interview with Italian newspaper La Repubblica, Gilmour says, "The band? It's over. Reunited because of the good cause (Live 8), to get over the bad relationship, and not to have regrets.
"I think I've had enough. I am 60. I don't want to work much anymore. It's an important part of my life, I have had enormous satisfactions, but now it's enough.
"The issue about Roger is irrelevant, because even without him I don't want to go on as Pink Floyd. I'm happy with my life.
"Playing as Pink Floyd is a business too big for me now. When you move as a band, all is gigantic, the expectations are enormous, the pressures very high. We have been asked to play one hundred gigs.
"I am fine as I live now. It was fantastic but now I don't feel like any more."