The frontman - whose group stepped in to take a headline slot at the world-famous UK music event in June when U2 were forced to pull out - insists the animated band learned from their mistakes after their performance received poor reviews.
He told BBC Radio 1's Newsbeat: "We were yet to change the dynamic entirely from the cartoon band acting purely as a film orchestra into something that had more of a human element to it.
"Basically, the difference between that and the next gig we did at Roskilde in Denmark, which was the same-sized audience, same age demographic, was I just communicated with the audience more."
Damon - who received rave reviews for his 2009 Glastonbury performance alongside 'Coffee and TV' rockers Blur - explained when performing at Roskilde he was more aware of the need to bond with the audience.
He said: "I didn't take for granted that if these people were going to be at the front then there had to be some kind of human interaction. It evolved into something with more human interaction. I know what people were reacting to."
Gorillaz originated as a cartoon concept band - with musicians playing behind a screen which showed images created by artist Jamie Hewlett - but dropped the curtain in favour of live performances with the artists on stage during their recent shows in support of third album 'Plastic Beach'.