The Blur frontman was one of the first acts to take to the stage at Britain's Glastonbury Festival on Friday (24Jun16), and grasped the opportunity to vocalise his thoughts on the so-called Brexit (Britain's exit from the European Union).
"I have a very heavy heart today," Damon said. "To my mind, democracy has failed us, because we were ill-informed. And I just want all of you to know, that when we leave here, we can change that decision. It is possible."
The audience, who had gathered to see the 48-year-old musician perform with The Orchestra of Syrian Musicians on the Pyramid Stage at the festival site, cheered and applauded Damon's comments.
Britain voted to exit the EU in the referendum on Thursday (23Jun16), with Prime Minister David Cameron then resigning his post, promising he will be out of the position by October (16).
Damon's speech was just one of the somewhat sombre moments that kicked off the annual world-famous festival on Friday.
English band Portishead were one of the first acts to perform, and opened their set with a tribute to MP Jo Cox, who was shot and stabbed on 16 June (16). After their cover of Abba's hit S.O.S was shown on video screens, the footage ended with a quote from mother-of-two, which read: "We have more in common than that which divides us."
Festival goers at the event have had to battle the changeable British weather conditions as they gather to watch their favourite musical acts perform, with the mud proving a problem as the band James prepared to take to the stage.
The All Sit Down musicians were the first act scheduled to perform on Friday morning, but were forced to delay their set due to the dangerous levels of mud in front of the Other Stage where their performance was due to take place.
Glastonbury organiser Michael Eavis came on stage to reassure fans, telling them: "Thank you for loving this festival as much as we do. You're the best audience in the world."
After wood chip was laid in front of the stage to make it safe for revellers, Eavis cut a ceremonial red ribbon across the front of the stage before James kicked off their set - 50 minutes late.