The group's former bassist and singer - whose band included guitarist Eric Clapton and drummer Ginger Baker - has now released his first solo album in almost 10 years, 'Silver Rails', after rediscovering his love of working in the studio.
He told BANG Showbiz: ''I kind of fell out of love with the recording process and life got in the way.
''Two years ago I worked all over the world. I've got this amazing band called the Big Blues Band, [a] three piece band and we were just playing.
''We went from South America to everywhere, all over the world, and that was fantastic, but also a little bit tiring for me in my age.''
The 70-year-old musician played with the 'I Feel Free' supergroup between 1966 and 1968, before they briefly united in 1993 and 2005, after which Jack said Cream were ''over''.
He went on to have a successful solo career after the band initially split but in 2003 he was forced to focus to deal with devastating health issues after being diagnosed with liver cancer, as a result of former drug abuse.
Jack had to have a transplant and afterwards said he felt as though he'd been given ''a miraculous extra lease on life'', which he described as a ''wonderful gift.''
The star said he was asked to record again by a friend in the industry and although he didn't name the pal, he admits he was persuasive enough to get him back into the studio.
Jack said: ''He has been really good to me over the years and had my back.
''He suggested, 'Would you fancy doing a studio album?' and I hadn't really thought about it. But then when I thought what a great time to do that because I've had this amazing life in music and I can look back over that and also kind of sideways, if you know what I mean.
''It turned out to be exactly the right thing to do. Everything just fell into place .... it was like magic.''
Jack's hypnotic album 'Silver Rails' is out now.