Jolie's shock split from husband Brad Pitt came as Handler was preparing to film a teaser for her Thursday night (22Sep16) Netflix talk show, and she couldn't resist letting fans know just what she thought about the now-estranged wife of her close friend Jennifer Aniston's ex.

"There are rumours that part of the problem was Brad was allegedly drinking and smoking too much weed," Handler said. "I wonder why he needed to self medicate. Maybe because he could have been spending the last 12 years at Lake Como (in Italy) hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages?"

Pitt and Jolie are parents to six kids - three biological and three adopted from Asia and Africa.

And irreverent Chelsea didn't stop there, calling Jolie "a f**king lunatic" and then joking, "We should all respect their privacy during this very difficult time. So, this will be the last time I speak of this... on TV. You can follow me on Twitter!"

Fans who then followed the comedienne on Twitter were treated to more barbs, joking about the former couple's Asian kids Pax and Maddox: "Angelina Jolie has filed for divorce from Brad Pitt. He wants the China; she wants Pax and Maddox. ##sorrycouldnthelpmyself."

Handler has had her claws out for Angelina for a while - during an appearance on TV show Watch What Happens Live in March, 2013, she called the Oscar winner a "demon" and added, "As a woman, I know when you see somebody walking across the room that's a bad girl. I just don't like Angelina Jolie. I don't think she's a girl's girl."

She also told Glamour magazine in 2010, "She just doesn't come off to me as a sincere woman. She seems like a woman that you'd really want to avoid."

She has also poked fun at the actress during stand-up comedy shows.