The comedian is pleading for help to track down the one-of-a-kind instruments, which are valued at a total of $55,000 (£34,000).
Editors at Tmz.com report that the guitars were stolen from a Los Angeles warehouse where Marin keeps his collection of rare instruments, many of which are considered works of art.
Marin is said to be asking local artists to look out for the pieces as the culprits could try to sell them.
The star is set to reunite with his comedy partner Tommy Chong to make their first film together in 20 years. Last year (13), Cheech and Chong's Animated Movie was released.