The 51-year-old actor was famously axed from the hit U.S. sitcom after a week-long bender fuelled by drugs topped off several months of scandal. He was replaced by Ashton Kutcher, but it seems Sheen still has a bone to pick with Lorre.

The Golden Globe winner called in to KIIS FM's Kyle And Jackie O Show on Wednesday (25Jan17), and revisited his feelings towards the sitcom creator in a no-holds barred chat.

First telling Lorre to "suck my f**king butt", Sheen continued: "He's the most miserable f**king d**chebag, the most talentless f**king sack of s**t of f**king stupid this side of La Brea."

Elsewhere in the interview, Sheen took the opportunity to apologise to Kutcher, after blasting the actor in several Twitter tirades when he was announced as his replacement.

"I was stupidly mean to him!" he admitted. "I overlooked the reality and difficulty of taking over a show... I should have been nicer.

"He was tasked with such an uphill struggle and I was more into my own ego that I wasn't aware of his struggles and for that I am regretful."

Kutcher starred as internet millionaire Walden Schmidt in seasons 9 to 12 of the programme.

Despite his sentiments, things are still awkward between the pair. Recalling meeting Kutcher at a Los Angeles Dodgers game back in September (16), Sheen claims the actor was hesitant around him, adding: "He thought he was going to catch a right cross and I just wanted to give him a hug.

"It was awkward, but I made it fine. I felt bad for him."

The Anger Management star’s interview continued in his usual eccentric style, with the actor outlandishly suggesting he's responsible for Woody Harrelson's career.

Cheers actor Harrelson became a Hollywood heavy hitter after starring in 1992’s White Men Can't Jump and Indecent Proposal in 1993 - both of which Sheen claims he was offered but turned down.

"I turned down White Men Can’t Jump, because I can’t, then I turned down Indecent Proposal," he alleged. "All my friends said, ‘Woody Harrelson should be sending you flowers, you gave him a career’."