Veteran character actress Carol Ann Susi has lost her battle with cancer.
The actress died aged 62 following a brief battle with the illness.
Susi was best known for her role as Mrs. Wolowitz on hit sitcom The Big Bang Theory, and a statement from the show's producers, Warner Bros. Television, and network CBS announced the sad news on Tuesday (11Nov14).
A statement reads: "The Big Bang Theory family has lost a beloved member today with the passing of Carol Ann Susi, who hilariously and memorably voiced the role of Mrs. Wolowitz.
"Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystery throughout the show's eight seasons. What was not a mystery, however, was Carol Ann's immense talent and comedic timing, which were on display during each unforgettable appearance.
"In addition to her talent, Carol Ann was a constant source of joy and kindness to all. Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly."
Among Susi's multiple Tv credits are Cheers, Seinfeld, Six Feet Under, The King of Queens, Ugly Betty, Married... With Children, and That '70s Show.
She also appeared in such films as Just Go With It, Cats & Dogs and Death Becomes Her.