The 68-year-old star appears as the interviewee on the latest episode of the UK series and journalist Piers, 52, questions Caitlyn about her life as Olympic gold medallist athlete Bruce Jenner before coming out as a trans woman in 2015 and completing gender reassignment surgery in January 2017.
During the Q&A session, Piers presented Caitlyn with an old doll of her as Bruce which was released in the wake of his 1976 decathlon victory at the Montreal Olympic Games.
Piers then asked: ''How does your physique compare now. Obviously certain areas?''
Prompting Caitlyn to reply: ''See you made a comment there and that is why you would get in trouble. OK? You just said, 'Certain areas?' That to a trans person is disrespectful. It is not funny. It is life. It is a very serious part of my life. I take that very seriously and so out of respect to myself and the community it is not something that you joke about. It is something as I said before ... this is serious. You can die over this issue. It is not a joke.''
Caitlyn then told Piers that she is trying to educate him on the issue, adding: ''I am trying to help you here Piers.''
And the confrontational host is forced to back down and apologise.
He said: ''I would not have known that. I was thinking I could make a flippant remark and I respect that.''
Having slammed his remarks, Caitlyn backs Piers into an apology, telling him she considered suicide before undergoing gender reassignment.
She said: ''There is a lot of pain in my life that I dealt with and it was not a joke and all the things I have done I take very seriously as it affects a lot of people ... I thought about suicide. That is the easy way out. That is how low you can get. Sometimes people do succeed in that and I thought, 'How stupid is that? I don't want my voice to be silenced. I want my voice to be heard? And I want to see if I can make a difference.''
Rather than apologise outright, Piers simply replied: ''Point taken.''
'Piers Morgan's Life Stories: Caitlyn Jenner' airs on Thursday at 9pm on ITV.
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