Talladega Nights, starring Will Farrell, was supposed to open big, box office analysts had predicted, but not this big. The film took in an estimated $47 million, making it the second-biggest opening for an original comedy ever, behind Bruce Almighty, which opened with $68 million in May, 2003. The movie was far ahead of Ferrell's previous biggest opening, Elf, which took in $31 million in November, 2003. As had been forecast, the three other new films had only so-so debuts. Paramount's animated Barnyard had the best of them, placing second with about $16 million. The British horror film The Descent, which drew smashing reviews, did not draw big crowds, taking in only $8.8 million. And The Night Listener, starring Robin Williams in a serious role, barely made the top ten with just $3.6 million. But the biggest disappointment may have been the 62-percent plunge of Miami Vice, which wound up in fourth place with $9.7 million, behind Pirates Of The Caribbean: Dead Man's Chest, which earned $11 million in its fifth week to bring its total booty to $379.7 million and putting it at No. 8 among the top domestic grossers of all time. It also excelled overseas, where it grossed an additional $57 million, to lift its worldwide total to $772 million.

The top ten films for the weekend, according to studio estimates compiled by Exhibitor Relations:
1. Talladega Nights, The Ballad of Ricky Bobby, $47,000,000; 2. Barnyard, $16,040,000; 3. Pirates of the Caribbean, Dead Man's Chest, $11,011,000; 4. Miami Vice, $9,683,000; 5. The Descent, $8,800,000; 6. John Tucker Must Die, $6,050,000; 7. Monster House, $6,000,000; 8. The Ant Bully, $3,900,000; 9. You, Me and Dupree, $3,603,000; 10. The Night Listener, $3,600,000.