The Mississippi-based group are calling for the episode to be cancelled amid claims the storyline will see Spears star as a TV host for a programme named 'Cruci-fixin's'.
AFA insist the show "mocks the crucifixion of Christ" and believe the designated 13 April (06) broadcast slot "further denigrates Christianity" because it is the eve of Christian celebration day, Good Friday.
AFA founder DON WILDMON says, "NBC is clearly mocking the Christian faith. I think they are smarting from the Book Of Daniel defeat that they suffered, and this is their way to get even."
NBC issued a statement in defence of the accusations, claiming Spears' role has yet to be determined.
It read, "Some erroneous information was mistakenly included in a press release describing an upcoming episode of Will + Grace, which, in fact, has yet to be written."
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