The singer - who is on hiatus from his band The Killers - launched into the classic 80s track during his show at the HMV Forum, much to the delight of the sell-out crowd.
Flowers was showcasing material from his debut solo LP 'Flamingo' and sent his fans wild with renditions of 'Magdalena', 'Only The Young', 'Jilted Lovers and Broken Hearts' and hit single 'Crossfire'.
He was happy to speak in-between tracks and flattered fans when introducing a slowed-down version of 'Welcome to Fabulous Las Vegas' by saying: "This land is my musical home, but this song is about my physical home."
Flowers - who was supported by American band Transfer - didn't ignore his Killers career and played 'Losing Touch' from the band's third studio album 'Day & Age'.
He came off stage to huge cheers and after the crowd chanted his name for a few minutes begging for him to return he came back for a two track encore comprised of 'The Clock Was Tickin'' and a stripped down acoustic version of The Killers hit 'When You Were Young'.