Brad Pitt and Angelina Jolie visited a children's cancer centre on Wednesday (29.12.10).

The showbiz couple - who raise six kids, Maddox, nine, Pax, seven, Zahara, five, Shiloh, four, and two-year-old twins Knox and Vivienne, together - were joined by Brad's parents and brother Doug on their brief trip to the St. John's Jane Pitt Paediatric Cancer Centre, which is in the actor's hometown of Springfield, Missouri.

Hospital spokesperson Cora Scott revealed: "They stayed about 45 minutes. It was a very nice visit."

Last year, Brad and Angelina, along with the actor's brother, sister and their families, donated $1 million to St. John's Foundation for Community Health and had the paediatric cancer unit dedicated to the 'Burn After Reading' star's mother Jane.

Cora added to People magazine: "Jane Pitt is a gem in our community. She's a very wonderful woman who cares so very much about the well being of children."

The trip was the first appearance made by the couple since returning from Namibia, where they spent Christmas with their children.

The couple went to the African nation where Shiloh was born, staying for a week in a villa at the Naankuse Wildlife Sanctuary and Lodge in The Village of Langstrand.

The family - arrived in the country on December 19, and reportedly spent their time on the beach as well as roaming in the nearby Nakuluft Mountains.

A source said: "They really enjoyed their trip.

"They were able to mingle with locals, visit Swakopmund and go to the beach there and also the beach in their neighbourhood."

The family stayed with a host family, headed by Dr. Rudie van Vuuren, a famous physician, cricket player and conservationist and his wife Marlice.