The couple will return for their ninth consecutive co-hosting run when the prizegiving takes place in November (16).
Paisley and Underwood broke the news on their social media accounts.
"So excited I am returning to host The 50th Annual CMA Awards w/ (with) Brad Paisley Nov. 2 on @abcnetwork! #CMAawards50," Underwood, 33, captioned an Instagram photo of herself and Paisley.
The Celebrity singer added: "Last year they let me pull my pants down on national tv, wonder what they will let me do this year, Carrie?"