U2 frontman Bono has been accused of cheating on his wife by controversial US radio host Rush Limbaugh.

While discussing a list of "ubersexuals" put out by an advertising agency, Limbaugh cited Pierce Brosnan, Jon Stewart, Donald Trump, Bill Clinton and Bono as making the list - and then said that the Irish rocker has a mistress.

When a caller on Limbaugh's show asked what basis the host had for his accusation, he replied, "You people are just going to have to trust me on this."

A spokesperson for U2 scoffs, "This is so absurd it doesn't deserve a response."

Bono has been married to his school sweetheart ALI HEWSON, the mother of his four children, for 23 years.