The 31-year-old rapper has revealed details of his fifth LP - his first solo record since 2017's 'I Decided' - which will see the star get real about being diagnosed with heart disease as a teenager and family.
Malone and Rocky feature on the track 'Wolves', which Sean says is about his family being close like a pack of wolves.
He explained: ''[That song is about] my family growing up. ''Everybody's in there, my grandma, my mom, my brother -- it's like they were a pack of wolves and they were the sweetest and strongest. It's one of my favourites on the album.''
Rocky also features on another song with Atlanta rapper MadeinTYO.
He said: ''Rocky had a verse on ['Wolves' originally], but he ended up doing the verse to another song that he and I felt fit a little better with the album.
''That's another song I got with MadeinTYO. But I just kept it dialed-in throughout.''
The track 'Lucky Me' sees the 'Bounce Back' star open up about his battle with heart disease and how his mother's holistic medicine helped mend him.
Recalling a scary moment when he was rushed to the emergency room after passing out, Sean told Entertainment Weekly: ''I couldn't even walk from one side of the room to the other without getting super-tired.
I passed out once in the shower and got rushed to the emergency room.''
On the song, he raps: ''Lucky me, I was diagnosed with a heart disease at 19.
''Doctors said they had to cut it open put a pacemaker on it to put it back on beat / 'Til my mother took me to holistic doctors and they prescribed me magnesium for two weeks / Went back to the regular doctors and they said, 'Huh? damn, looks like we don't need to proceed.'''
There is also a brief cameo from Mill and Diddy on another song.
He said: ''There's a song where Meek Mill just says two lines, and Puff had a couple of lines.''
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