The beauty dated the hip-hop artist before he got together with his wife Kim Kardashian, and they have traded barbed insults over the years.
However, during an appearance on U.S. TV show Watch What Happens Live on Sunday (25Oct15), she point-blank refused to be drawn on the feud.
A segment called Plead the Fifth features stars given three difficult questions, with the option of deciding to skip just one of them. Amber took the game a step further by saying 'no' to each of the questions, much to host Andy Cohen's annoyance.
"Not doing it," she replied, when asked which of the Kardashians interests her least. "No, I am not talking about Kanye West or the Kardashians. Not in a negative way... but they are not relevant to my life."
Andy stated she had done "the worst job" of any guest during the game because of her lack of involvement, but it didn't stop him attempting to grill her for information, with the host asking his guest to dream up one kind thing to say about several of her enemies.
After a period of consideration she stated pregnant star Kim, who is already mother to two-year-old daughter North, "makes beautiful babies" and that Kanye "makes really good music".
The awkward conversation continued when Amber spoke about a recent walk she organised which she hoped would empower women. She was incensed when several celebrities she asked to be involved requested a fee, but she turned down Andy's request to name and shame them.
"I really don't want to put them out there, Andy," she said. "But I feel like, as a woman, they should have jumped on board. I was called a s**t when I was still a virgin. I got ridiculed in high school because of what they assumed I'd done."
Amber also refused to remove her sunglasses during the interview, saying, "I'm drunk, sorry, I'm not doing that. I'm like the worst guest ever on this show," prompting Andy to reply, "You're in the running."