The busty beauty has lodged papers in a California court, revealing they officially separated on Monday (22Sep14).
She cites irreconcilable differences for the split.
Rose, who previously dated Kanye West, is seeking full legal and physical custody of their one-year-old son Sebastian.
The documents, obtained by Tmz.com, also reveal the estranged couple signed a pre-nuptial agreement before its wedding in July, 2013.
Khalifa has yet to comment on the break-up news, which emerges one month after they appeared to be all loved up on the red carpet at the MTV Video Music Awards in Los Angeles.