Amanda Knox has been ordered to stand trial for a second time over the death of British student Meredith Kercher in Italy in 2007.
Knox, 25, and her former boyfriend, Raffaele Sollecito, were previously convicted of killing the 21 year old and spent four years in jail before they were both acquitted and freed on appeal in 2011.
However, Italy's highest court, the Court of Cassation in Rome, overturned the acquittal on Tuesday (26Mar13) and a judge ordered a new trial for the pair.
In arguments heard at the court on Monday (25Mar13), the day before the ruling, prosecutors urged the judges overseeing the case to "make sure the final curtain does not drop on this shocking and dire crime".
Knox, who was initially sentenced to 26 years in prison for Kercher's murder, returned to her native Seattle, Washington after being freed from jail 18 months ago, and she will not be required to return to Italy to take part in her second court case as Italian law states defendants can be tried in absentia.
If found guilty, she could face extradition from the U.S.
Knox says of the retrial, "I believe that any questions as to my innocence must be examined by an objective investigation and a capable prosecution.
"The prosecution responsible for the many discrepancies in their work must be made to answer for them, for Raffaele's sake, my sake, and most especially for the sake of Meredith's family. Our hearts go out to them.
"No matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity."
Francesco Maresca, a lawyer representing Kercher's relatives, adds, "I am happy the Supreme court has seen the faults in the acquittal and I trust the next trial will be fair and balanced."
Knox's story was played out on the small screen in a Tv movie starring Hayden Panettiere, who recently apologised to Kercher's family for portraying her accused killer in the Tv drama.
Knox has written a book about her experiences and it is due for release next month (Apr13).